Methods for the Diagnosis and Treatment of Neurological and Neurodegenerative Diseases, Disorders and Associated Processes

摘要

The invention generally relates to methods for the diagnosis and treatment of neurological and neurodegenerative diseases, disorders, and associated processes. Specifically, the present invention is directed toward methods to determine prognosis, diagnosis or efficacy of a therapeutic regimen by using a detectable label to measure levels of alpha-synuclein.

主权项

1. A method to determine the prognosis, diagnosis, efficacy of a therapeutic regimen, or predict subject response to a therapeutic agent to treat an alpha-synuclein related disease or disorder in a subject comprising contacting a biological sample from a subject with a labeled moiety to detect the level of alpha-synuclein in the sample wherein the level is compared with a reference standard level, wherein a difference in the level in the sample as compared to the reference level allows one to determine the prognosis, diagnosis, efficacy of the therapeutic regimen or predict subject response to a therapeutic agent to treat an alpha-synuclein related disease or disorder.