摘要 |
<p>A BACE 1 inhibitor containing, as an active ingredient, any one of a compound represented by the formula (I): (wherein ring A is an optionally substituted carbocyclic group or optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR<SUP>1</SUP> (R<SUP>1</SUP> is hydrogen or lower alkyl); R<SUP>2a</SUP>, R<SUP>2b</SUP>, R<SUP>3a</SUP>, R<SUP>3b</SUP>, R<SUP>4a</SUP>, and R<SUP>4b</SUP> each independently is hydrogen, halogeno, hydroxy, etc.; n and m each independently is an integer of 0-3, provided that n+m is 1-3; and R<SUP>5</SUP> is hydrogen, optionally substituted lower alkyl, etc.), a pharmaceutically acceptable salt thereof, and a solvate of either.</p> |
申请人 |
SHIONOGI & CO., LTD.;KOBAYASHI, NAOTAKE;UEDA, KAZUO;ITOH, NAOHIRO;SUZUKI, SHINJI;SAKAGUCHI, GAKU;KATO, AKIRA;YUKIMASA, AKIRA;HORI, AKIHIRO;KORIYAMA, YUJI;HARAGUCHI, HIDEKAZU;YASUI, KEN;KANDA, YASUHIKO |
发明人 |
KOBAYASHI, NAOTAKE;UEDA, KAZUO;ITOH, NAOHIRO;SUZUKI, SHINJI;SAKAGUCHI, GAKU;KATO, AKIRA;YUKIMASA, AKIRA;HORI, AKIHIRO;KORIYAMA, YUJI;HARAGUCHI, HIDEKAZU;YASUI, KEN;KANDA, YASUHIKO |