发明名称 |
COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF MELANOMA USING PD-L1 ISOFORMS |
摘要 |
The present invention relates to compositions and methods for identifying, assessing, preventing, and treating melanoma, A variety of PD-L1 isoform biomarkers are provided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or activity of one or more of the biomarkers is associated with melanoma status. |
申请公布号 |
US2016340407(A1) |
申请公布日期 |
2016.11.24 |
申请号 |
US201515110808 |
申请日期 |
2015.01.14 |
申请人 |
Dana-Farber Camcer Institute, Inc. |
发明人 |
Hodi F. Stephen;Zhou Jun;Freeman Gordon J.;Li Jingjing;Wu Xinqi |
分类号 |
C07K14/705;A61K9/00;C07K16/28;G01N33/574;C07K16/30;A61K38/17;G01N33/50;C12Q1/68;A61K45/06;A61K39/395 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated polypeptide selected from the group consisting of polypeptides comprising an amino acid sequence listed in Table 2, and fragments thereof, and polypeptides comprising an amino acid sequence having at least 80% identity across their full length with a nucleic acid sequence listed in Table 2, and fragments thereof. |
地址 |
Boston MA US |