| 主权项 |
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein A is selected from the group consisting of:
(1) —C3-9cycloalkyl,(2) —C3-9cycloalkenyl,(3) —C2-10cycloheteroalkyl, and(4) —C2-10cycloheteroalkenyl, wherein each cycloalkyl, cycloalkenyl, cycloheteroalkyl and cycloheteroalkenyl is unsubstituted or substituted with one, two or three substituents selected from Ra; B is selected from the group consisting of:
(1) —(CH2)u-aryl,(2) —(CH2)u-heteroaryl,(3) —(CH2)u-aryl-aryl,(4) —(CH2)u—N(Rg)—(CH2)u-aryl,(5) —(CH2)u—N(Rg)—(CH2)u-heteroaryl,(6) —(CH2)u—O—(CH2)u-aryl,(7) —(CH2)u—O—(CH2)u-aryl-aryl,(8) —(CH2)u—O—(CH2)u-heteroaryl,(9) —(CH2)u—C3-6cycloalkyl,(10) —(CH2)u—O—(CH2)u—C3-6cycloalkyl,(11) —(CH2)u—C2-6cycloheteroalkyl, and(12) —(CH2)u—O—(CH2)u—C2-6cycloheteroalkyl, wherein each CH2, cycloalkyl, cycloheteroalkyl, aryl and heteroaryl is unsubstituted or substituted with one, two, three, four or five substituents selected from Rb; T is selected from the group consisting of:
(1) CH,(2) N, and(3) N-oxide; U is selected from the group consisting of:
(1) CH,(2) N, and(3) N-oxide; V is selected from the group consisting of:
(1) CH,(2) N, and(3) N-oxide; W is selected from the group consisting of:
(1) CH,(2) N, and(3) N-oxide, provided that no more than three of T, U, V and W are selected from N and N-oxide; Y is selected from the group consisting of:
(1) —(CH2)xO—,(2) —O—(CH2)x,(3) —(CH2)x—NRf—,(4) —(CH2)x—S—,(5) —(CH2)x—CH2—,(6) —(CH2)x—C(O)—,(7) —(CH2)x—CF2—, and(8) —CF2—(CH2)x—, wherein CH2 is unsubstituted or substituted with one or two substituents selected from Ri; Z is selected from the group consisting of:
(1) —C0-6alkyl-CO2H,(2) —C0-6alkyl-CO2Rj,(3) —C0-6alkyl-C(O)NHRh,(4) —C0-6alkyl-C(O)NHSO2Rh,(5) —C0-6alkyl-SO2NHC(O)Rh,(6) —C0-6alkyl-heteroaryl, and(7) —C0-6alkyl-cycloheteroalkyl, wherein cycloheteroalkyl is selected from the group consisting of: wherein each alkyl, cycloheteroalkyl and heteroaryl is unsubstituted or substituted with one to five substituents selected from C1-6alkyl; each R1 is independently selected from the group consisting of:
(1) hydrogen,(2) halogen,(3) —(CH2)s—OC1-6alkyl,(4) —(CH2)s—OH,(5) —CN, and(6) —C1-6alkyl, wherein CH2 and alkyl are unsubstituted or substituted with one, two or three halogens; each R2 is independently selected from the group consisting of:
(1) hydrogen,(2) —(CH2)s—O—C1-6alkyl,(3) —C1-6alkyl,(4) —C3-6cycloalkyl, and(5) —C2-4cycloheteroalkyl, wherein each CH2, alkyl, cycloalkyl and cycloheteroalkyl is unsubstituted or substituted with one, two or three substituents selected from halogen, OH, —C1-6alkyl and —OC1-6alkyl; each R3 is independently selected from the group consisting of:
(1) hydrogen,(2) halogen,(3) —(CH2)s—OC1-6alkyl,(4) —(CH2)s—OH,(5) —CN, and(6) —C1-6alkyl, wherein CH2 and alkyl are unsubstituted or substituted with one, two or three substituents selected from halogen, OH, and OC1-6alkyl; each Ra is independently selected from the group consisting of:
(1) —C1-6alkyl,(2) halogen,(3) —(CH2)u—OC1-6alkyl,(4) —ORe,(5) —S(O)uRe,(6) —S(O)uNRcRd,(7) —N(Rc)S(O)pRe,(8) —NRcRd,(9) —C(O)Re,(10) —OC(O)Re,(11) —CO2Re,(12) —N(Rc)C(O)Re,(13) —N(Rc)C(O)ORe,(14) —N(Rc)C(O)NRcRd,(15) —C(O)NRcRd,(16) —CN,(17) —CF3,(18) —OCF3,(19) —OCHF2,(20) —(CH2)raryl,(21) —(CH2)rheteroaryl,(22) —(CH2)r—C3-6cycloalkyl,(23) —(CH2)r—C3-6cycloalkenyl,(24) —(CH2)r—C2-5cycloheteroalkyl, and(25) —(CH2)r—O—(CH2)r—C3-6cycloalkyl, wherein each CH2, alkyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, aryl and heteroaryl is unsubstituted or substituted with one to four substituents selected from: halogen, —C1-6alkyl, —(CH2)w—OH, —O—C1-6alkyl, —CF3, —CN, —(CH2)v—C3-6cycloalkyl, SH, and —SO2—C1-6alkyl; each Rb is independently selected from the group consisting of:
(1) —C1-10alkyl,(2) —C2-10alkenyl,(3) —(CH2)v—CF3,(4) —O(CH2)vCF3,(5) —OCHF2,(6) —S(CH2)vCF3,(7) —(CH2)vSC1-10alkyl,(8) halogen,(9) oxo,(10) —(CH2)vCN,(11) —(CH2)vOH(12) —(CH2)vOC1-10alkyl,(13) —(CH2)vOC2-10alkenyl,(14) —O—(CH2)vOC1-10alkyl,(15) —(CH2)v—O—(CH2)vC3-6cycloalkyl,(16) —(CH2)v—O—(CH2)vC2-10cycloheteroalkyl,(17) —(CH2)v—O—(CH2)v-aryl,(18) —(CH2)v—O—(CH2)v-heteroaryl,(19) —(CH2)v O(CH2)vN(Rc)S(O)qRe,(20) —(CH2)v O(CH2)vS(O)qRe,(21) —(CH2)v O(CH2)vS(O)qNRcRd,(22) —(CH2)v O(CH2)vNRcRd,(23) —C(O)Re,(24) —OC(O)Re,(25) —CO2Re,(26) —C(O)NRcRd,(27) —N(Rc)C(O)Re,(28) —N(Rc)C(O)ORe,(29) —N(Rc)C(O)NRcRd,(30) —N(Rc)S(O)qRe,(31) —S(O)qRe,(32) —S(O)qNRcRd,(33) —NRcRd,(34) —O(CH2)vO—C3-6cycloalkyl,(35) —O(CH2)vO—C2-5cycloheteroalkyl,(36) —O(CH2)vO-aryl,(37) —O(CH2)vO-heteroaryl,(38) —(CH2)vC3-6cycloalkyl,(39) —(CH2)vC2-10cycloheteroalkyl,(40) —(CH2)v-aryl, and(41) —(CH2)v-heteroaryl, wherein each CH, CH2, alkyl, alkenyl, cycloalkyl, cycloheteroalkyl, aryl and heteroaryl is unsubstituted or substituted with one, two or three substituents selected from: halogen, —C1-6alkyl, —(CH2)w—OH, —O—C1-6alkyl, —CF3, —CN, —(CH2)v—C3-6cycloalkyl, SH, and —SO2—C1-6alkyl; each Rc is independently selected from the group consisting of:
(1) hydrogen,(2) C1-10alkyl,(3) C3-6cycloalkyl,(4) C2-5cycloheteroalkyl,(5) aryl, and(6) heteroaryl, wherein each alkyl, cycloalkyl, cycloheteroalkyl, aryl and heteroaryl is unsubstituted or substituted with one to three substituents selected from C1-6alkyl; each Rd is independently selected from the group consisting of:
(1) hydrogen,(2) C1-10alkyl,(3) C3-6cycloalkyl,(4) C2-5cycloheteroalkyl,(5) aryl, and(6) heteroaryl, wherein each alkyl, cycloalkyl, cycloheteroalkyl, aryl and heteroaryl is unsubstituted or substituted with one to three substituents selected from C1-6alkyl; each Re is independently selected from the group consisting of:
(1) hydrogen,(2) C1-10alkyl,(3) C3-6cycloalkyl,(4) C2-5cycloheteroalkyl,(5) aryl, and(6) heteroaryl, wherein each alkyl, cycloalkyl, cycloheteroalkyl, aryl and heteroaryl is unsubstituted or substituted with one to three substituents selected from C1-6alkyl; each Rf is independently selected from the group consisting of:
(1) hydrogen,(2) C1-6alkyl, and(3) C3-6cycloalkyl; each Rg is independently selected from the group consisting of:
(1) hydrogen,(2) halogen,(3) C1-6alkyl, and(4) C3-6cycloalkyl; each Rh is independently selected from the group consisting of:
(1) hydrogen,(2) —C1-10alkyl,(3) —C2-10 alkenyl,(4) —C3-6 cycloalkyl,(5) C3-6 cycloalkyl-C1-10alkyl-,(6) —C2-5cycloheteroalkyl,(7) C2-5cycloheteroalkyl-C1-10alkyl-,(8) aryl,(9) heteroaryl,(10) aryl-C1-10alkyl-, and(11) heteroaryl-C1-10alkyl-, wherein alkyl, alkenyl, cycloalkyl, cycloheteroalkyl, aryl and heteroaryl are unsubstituted or substituted with one to four substituents selected from C1-6alkyl; each Ri is independently selected from the group consisting of:
(1) hydrogen,(2) halogen,(3) —C1-6alkyl,(4) —(CH2)s—O—C1-6alkyl,(5) —(CH2)sOH,(6) —N(Rc)S(O)2Re,(7) —S(C1-6alkyl),(8) —(CH2)sSO2C1-6alkyl,(9) —(CH2)sSO2—(CH2)t—C3-6cycloalkyl,(10) —S(O)2NRcRd,(11) —NRcRd,(12) —C(O)Re,(13) —OC(O)Re,(14) —CO2Re,(15) —(CH2)sCN,(16) —C(O)NRcRd,(17) —N(Rc)C(O)Re,(18) —N(Rc)C(O)ORe,(19) —N(Rc)C(O)NRcRd,(20) —CF3,(21) —OCF3,(22) —OCHF2,(23) —C3-6cycloalkyl, and(24) —C2-5cycloheteroalkyl, wherein each CH2, alkyl, cycloalkyl and cycloheteroalkyl is unsubstituted or substituted with one, two, three or four substituents selected from: —C1-6alkyl and halogen; each Rj is independently selected from the group consisting of:
(1) —C1-6alkyl,(2) —C3-6cycloalkyl, and(3) -aryl-C1-6alkyl, wherein each alkyl, cycloalkyl and aryl is unsubstituted or substituted with one to three substituents selected from Rk; each Rk is independently selected from the group consisting of:
(1) —C1-6alkyl,(2) —ORe,(3) —N(Rc)S(O)pRe,(4) halogen,(5) —S(O)pRe,(6) —S(O)pNRcRd,(7) —NRcRd,(8) —C(O)Re,(9) —OC(O)Re,(10) —CO2Re,(11) —CN,(12) —C(O)NRcRd,(13) —N(Rc)C(O)Re,(14) —N(Rc)C(O)ORe,(15) —N(Rc)C(O)NRcRd,(16) —CF3,(17) —OCF3,(18) —OCHF2,(19) —C3-6cycloalkyl, and(20) —C2-5cycloheteroalkyl; n is independently selected from: 1 and 2; m is independently selected from: 1 and 2; each p is independently selected from: 0, 1 and 2; each q is independently selected from: 0, 1 and 2; each r is independently selected from: 1, 2, 3 and 4; each s is independently selected from: 0, 1, 2 and 3; each t is independently selected from: 0, 1, 2, 3 and 4; each u is independently selected from: 0, 1, 2 and 3; each v is independently selected from: 0, 1, 2, 3 and 4; each w is independently selected from: 0, 1, 2 and 3; and each x is independently selected from: 0, 1 and 2. |
