发明名称 |
BISPECIFIC OR-GATE CHIMERIC ANTIGEN RECEPTOR RESPONSIVE TO CD19 AND CD20 |
摘要 |
A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR. |
申请公布号 |
WO2016100232(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
WO2015US65620 |
申请日期 |
2015.12.14 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;SEATTLE CHILDREN'S HOSPITAL DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE |
发明人 |
CHEN, YVONNE Y.;ZAH, EUGENIA;JENSEN, MICHAEL C. |
分类号 |
C07K16/28;A61K35/17;C07K14/705;C07K16/46;C12N5/0783;C12N15/62;C12N15/85 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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