NOVEL PROCESS FOR PREPARATION OF AMINO ACID DERIVATIVES

摘要

PROBLEM TO BE SOLVED: To provide an alternative process for preparation of amino derivatives.SOLUTION: In particular, the present application relates to an improved process for manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II).SELECTED DRAWING: None