Molecular constructs with targeting and effector moieties

摘要

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

主权项

1. A molecular construct comprising a first linker unit and a second linker unit, wherein,
the first linker unit comprises a first center core comprising a plurality of amine groups, and a first linking arm and optionally a first coupling arm that are respectively linked to the first center core; the second linker unit comprises a second center core comprising a plurality of amine groups, and a second linking arm and optionally a second coupling arm that are respectively linked to the second center core; and the first and second linker units are coupled to each other via copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction, strained-promoted azide-alkyne click chemistry (SPAAC) reaction or inverse electron demand Diels-Alder (iEDDA) reaction occurred between any of the followings: the first and second center cores, the first coupling arm and the second center core, the first and second coupling arms, or the first center core and the second coupling arm.