RADIOTRACER COMPOSITIONS AND METHODS

摘要

The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.

主权项

1. A radiopharmaceutical composition which comprises:
(i) a radiotracer that has a radioactive concentration of 500-700 MBq/mL and which comprises a c-Met binding peptide of Formula I labelled with 18F:
Z1-[cMBP]-Z2   (I) (ii) a radioprotectant which comprises 4-aminobenzoic acid, or a salt thereof with a biocompatible cation; (iii) a biocompatible carrier which comprises aqueous ethanol having an ethanol content of 0.1 to 10% v/v;in a form suitable for mammalian administration;
where: cMBP is the c-Met binding peptide having the amino acid sequence:Ala-Gly-Ser-Cysa-Tyr-Cysc-Ser-Gly-Pro-Pro-Arg-Phe-Glu-Cysd-Trp-Cysb-Tyr-Glu-Thr-Glu-Gly-Thr-Gly-Gly-Gly-Lys wherein Cysa-d are each cysteine residues such that residues a and b as well as c and d are cyclised to form two separate disulfide bonds; Z1 is attached to the N-terminus of cMBP, and is MIG; Z2 is attached to the C-terminus of cMBP and is MIG, MIG is independently a metabolism inhibiting group which is a biocompatible group which inhibits or suppresses in vivo metabolism of the cMBP peptide; the Lys residue of the cMBP is labelled with 18F.