ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1

摘要

Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell through the PD-1 pathway is also disclosed.

主权项

1. An isolated polynucleotide encoding an antibody or antibody fragment which binds to human PD-1, wherein the antibody or antibody fragment comprises
a. at least one CDR selected from the group consisting of SEQ ID NOs: 9, 10, 11, 15, 16 and 17; and/or b. at least one CDR selected from the group consisting of SEQ ID NOs: 12, 13, 14, 18, 19 and 20.