发明名称 |
BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF |
摘要 |
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone (4,5-α-epoxy-14-hydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxycodone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxycodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. |
申请公布号 |
US2016168160(A1) |
申请公布日期 |
2016.06.16 |
申请号 |
US201514952348 |
申请日期 |
2015.11.25 |
申请人 |
KemPharm, Inc. |
发明人 |
Mickle Travis;Guenther Sven;Bera Sanjib;Bera Bindu;Kanski Jaroslaw;Martin Andrea |
分类号 |
C07D489/04 |
主分类号 |
C07D489/04 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising oxycodone covalently attached to at least one carboxylic acid, a derivative thereof, a salt thereof, or a combination thereof. |
地址 |
Celebration FL US |