发明名称 |
Compounds With Mixed Pde-Inhibitory and Beta-Adrenergic Antagonist or Partial Agonist Activity For Treatment of Heart Failure |
摘要 |
This invention provides compounds that possess inhibitory activity against beta-adrenergic receptors and phosphodiesterase PDE, including phosphodiesterase 3 (PDE3). This invention further provides pharmaceutical compositions comprising such compounds; methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine; and methods of preparing pharmaceutical compositions and compounds that possess inhibitory activity against beta-adrenergic receptors and PDE.
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申请公布号 |
US2008090827(A1) |
申请公布日期 |
2008.04.17 |
申请号 |
US20050791893 |
申请日期 |
2005.11.08 |
申请人 |
ARTESIAN THERAPEUTICS, INC. |
发明人 |
TAYLOR MALCOLM G.;KLENKE BURKHARD;SUZDAK PETER D.;MAZHARI REZA |
分类号 |
A61K31/50;A61K31/444;A61P9/00;A61P25/06;A61P25/08;A61P27/02;C07D237/04;C07D401/04 |
主分类号 |
A61K31/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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