Abstract The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholes-terolemia.
申请公布号
AU2015200427(B2)
申请公布日期
2016.11.10
申请号
AU20150200427
申请日期
2015.01.29
申请人
Pfizer Inc.;Rinat Neuroscience Corporation
发明人
Liang, Hong;Abdiche, Yasmina Noubia;Chaparro Riggers, Javier Fernando;Gomes, Bruce Charles;Hawkins, Julie Jia Li;Pons, Jaume;Qiu, Xiayang;Strop, Pavel;Wang, Yuli