| 发明名称 |
Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase |
| 摘要 |
Compounds of formula (I)where R1 is hydrogen; R2 is nitro, cyano or halo(lower)alkyl; R3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R4 is a group CR6R7R8 wherein R6 and R7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R8 is hydrogen; its prodrug and a salt thereof.
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| 申请公布号 |
US6384080(B1) |
申请公布日期 |
2002.05.07 |
| 申请号 |
US20010509541 |
申请日期 |
2001.04.23 |
| 申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD. |
发明人 |
OKU TERUO;SAWADA KOZO;KURODA AKIO;INOUE TAKAYUKI;KAYAKIRI NATSUKO;SAWADA YUKI;MIZUTANI TSUYOSHI |
| 分类号 |
A61P1/00;A61K31/166;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P15/00;A61P15/10;A61P17/00;A61P27/06;A61P37/08;A61P43/00;C07C227/30;C07C227/32;C07C237/28;C07D207/14;C07D207/48;C07D211/58;C07D213/40;C07D235/10;C07D235/14;C07D307/22;C07D317/58;C07D333/20;C07D521/00;(IPC1-7):A61K31/18;C07C235/00 |
主分类号 |
A61P1/00 |
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