MIXTURE OF ANTIBIOTICS PRODUCED BY A SPECIES OF ACTINOPLANES

摘要

A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery.