Compositions and methods for treatment of ovarian cancer

摘要

The disclosure provides compositions and methods for treating an ovarian cancer in a subject. More specifically, the disclosure provides microRNA (miRNA) inhibitor molecules that target to different miRNAs for treating different types of ovarian cancers in a subject. Furthermore, different modifications of miRNA inhibitor molecules as well as different derivatives of miRNA inhibitor molecules are also described.

主权项

1. A method of inhibiting proliferation of ovarian cancer cells, the method consisting of introducing into the cells of a patient in need thereof a composition consisting of a compound which inhibits expression or activity of a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 16 and 38, and a pharmaceutically acceptable carrier, wherein said compound inhibits proliferation of ovarian cancer cells.