Synthesis of isohexide dicarbamates and derivatives thereof

摘要

Dicarbamates of the reduction products of 2-hydroxymethyl-5-furfural (HMF) and a method of preparing the same are described. The method involves reacting a mixture of an isohexide and a cynate salt in a non-aqueous solvent, with a miscible acid having a pKa of about 3.7 or less. The dicarbamates of HMF-reduction products can serve as precursor materials from which various derivative compounds can be synthesized.

主权项

1. A process for preparing dicarbamates of reduction products of HMF, the process comprising: providing a mixture of a HMF-reduction product with a cyanate salt in an inert organic solvent, reacting said mixture with an acid having a pKa≦3.7.