发明名称 |
Hidtil ukendte aminoglycosider og anvendelser deraf ved behandling af genetiske lidelser |
摘要 |
A new class of paromomycin-derived aminoglycosides (Formula I), which exhibit efficient stop-codon mutation suppression activity, low cytotoxicity and selectivity towards eukaryotic cells are provided. Also provided are processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders. |
申请公布号 |
DK2390255(T3) |
申请公布日期 |
2016.11.07 |
申请号 |
DK20110173958T |
申请日期 |
2007.04.10 |
申请人 |
Technion Research & Development Foundation Ltd. |
发明人 |
BAASOV, Timor;Ben-Yosef, Tamar;Nudelman, Igor;Rebibo-Sabbah, Annie;Shallom-Shezifi, Dalia;Hainrichson, Mariana |
分类号 |
C07H5/06;A61K31/7036;A61P43/00 |
主分类号 |
C07H5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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