PEPTIDE, PRODUCTION AND USE THEREOF

摘要

PEPTIDE PRODUCTION AND USE THEREOF A peptide represented by the formula: ¢I! wherein R1 represents an oil-soluble group; R2 and R5 represent a hydrogen atom or a lower alkyl group; R3represents an aliphatic group which may have O or S; R4 represents a heterocyclic-substituted lower alkyl group; R6 represents a hydrogen atom, a lower alkyl group or an aromatic cyclic group; X represents a group having an aromatic ring; n represents an integer of 0 or more and m represents an integer of 2 or more, or a salt thereof exhibits a marked endothelin receptor-antagonistic action, and the peptide ¢I! is pharmaceutically useful as a therapeutic agent for hypertension, cardiovascular disease and renal disease, for instance.