| 摘要 |
<p>Novel compounds having three substituents in the cyclic partial structure thereof, such as a pyrrolidine or a benzene ring, for example, homophenylalanyl-trans-4-((S)-3-amino-2-hydroxypropionylamino)proline 5-indanylamide and N-(3-phenylpropyl)-3-((S)-2-hydroxy-3-aminopropionylamino)-5-(D-homophenylalanylamino)-benzamide. These compounds act on pathogenic microorganisms which have acquired tolerance to the existing antimicrobials and elevate the sensitivity to the antimicrobials, thus making them nontolerant. When used together with the antimicrobials, these compounds can efficaciously establish the prevention and/or treatment of microbial infectious diseases.</p> |
