摘要 |
<p>The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R1 represents halogeno or C¿1-3?alkyl; X?1¿ represents -O-; R2 is selected from one of the following three groups: 1) C¿1-5?alkylR?3¿ (wherein R3 is piperidin-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C¿1-4?alkyl, C1-4hydroxyalkyl and C1-4alkoxy; 2) C2-5alkenylR?3¿ (wherein R3 is as defined hereinbefore); 3) C¿2-5?alkynylR?3¿ (wherein R3 is as defined hereinbefore); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.</p> |