| 摘要 |
FIELD: metalloorganic compounds, medicine, pharmacy. ^ SUBSTANCE: invention relates to palladium-substituted derivatives of bacteriochlorophyll of the formulas (I) ^ ^ (I') ^ ^ or (I'') ^ ^ wherein A represents hydroxyl (OH), OR1- -O-(CH2)n-Y, -NH-(CH2)n-Y, -O-(CH2)2-OH, -NH-(CH2)2-NH-BOC or -N-(CH2-CH=CH2)2 wherein R1 represents Na+, K+, (Ca2+)0.5, (Mg2+)0.5, Li+, NH+4, +NH3-C-(CH2OH)3, +NH3-CH2-(CHOH)4-CH2OH, +NH2-(CH3)-CH2-(CHOH)4-CH2OH or +N-(Cn'H2n+1)4; R2 represents hydrogen atom (H) or (C1-C12)-alkyl for compound of the formula (I'0, and R2 represents hydrogen atom (H), hydroxyl (OH) or COOR4 for compound of the formula (I) wherein R4 represents (C1-C12)-alkyl or (C3-C12)-cycloalkyl; R3 represents hydrogen atom (H) or (C1-C12)-alkyl for compound of the formula (I'), and R3 represents hydrogen atom (H), hydroxyl (OH) or (C1-C12)-alkyl or alkoxy-group for compound of the formula (I); n = 1, 2, 3, 4, 5 or 6; Y represents -NR'1NR'2 or -+NR'1R'2R'3X wherein each R'1, R'2 and R'3 represent independently of one another -CH3 or -CH5; X represents fluorine (F), chlorine (Cl), bromine (Br) or iodine (J) atom; n' = 1, 2, 3 or 4 and wherein * represents asymmetric carbon atom, and --- means an ordinary saturated bond or double unsaturated bond. Invention relates to pharmaceutical composition eliciting ability for detection or treatment of tumors and comprising at least one compound of the formula (I), (I') or (I'') and to three methods for preparing compound of the formula (I). ^ EFFECT: improved preparing method, valuable medicinal properties of compounds. ^ 21 cl, 5 tbl, 11 dwg, 23 ex |
