| 发明名称 |
HIV protease inhibitors |
| 摘要 |
The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.
|
| 申请公布号 |
US6852711(B2) |
申请公布日期 |
2005.02.08 |
| 申请号 |
US20020299510 |
申请日期 |
2002.11.19 |
| 申请人 |
AGOURON PHARMACEUTICALS, INC. |
发明人 |
BOYER, JR. FREDERICK EARL;DOMAGALA JOHN MICHAEL;ELLSWORTH EDMUND LEE;GAJDA CHRISTOPHER ANDREW;HAGEN SUSAN ELIZABETH;LOVDAHL MICHAEL JAMES;LUNNEY ELIZABETH ANN;MARKOSKI LARRY JAMES;PRASAD JOSYULA VENKATA NAGENDRA VARA;TAIT BRADLEY DEAN |
| 分类号 |
C07D233/64;A61K31/351;A61K31/381;A61K31/426;A61K31/427;A61K31/428;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/443;A61K31/4433;A61P31/14;A61P31/18;C07D207/333;C07D209/12;C07D209/30;C07D213/30;C07D213/71;C07D231/12;C07D235/06;C07D235/26;C07D239/26;C07D239/42;C07D241/44;C07D277/20;C07D277/24;C07D277/46;C07D277/82;C07D307/12;C07D307/42;C07D309/32;C07D333/16;C07D333/32;C07D333/62;C07D405/06;C07D405/12;C07D405/14;C07D407/06;C07D409/06;C07D409/12;C07D409/14;C07D413/06;C07D417/06;C07D417/12;C07D417/14;(IPC1-7):A61K31/33;A61K31/35;C07D277/00;C07D309/00;C07D315/00 |
主分类号 |
C07D233/64 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
