PROCEDE POUR LA PREPARATION DES DERIVES DU 1-PHENOXY-3 AMINOPROPAN-2-OLE

摘要

The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula -O-CH2-CH-CH2-NH-X ¦ OH and the aldehyde condensation products and acid addition salts thereof wherein X is selected from the group consisting of -C=CH-C and ¦ PARALLEL CH3O -CH-CH2-CH ¦¦ CH3OH wherein the phenyl ring I may have attached to it up to three similar or different substituents selected from the group consisting of alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, alkinyloxy, benzyloxy, phenyl, halogen and -NR1R2, wherein R1 is selected from alkyl and acyl, and R2 is selected from hydrogen and alkyl and n is 1, 2 or 3; and to the production thereof by a method selected from (A) reacting 1-phenoxy-3-amino-propan-2-ol having the formula -O-CH2-CH-CH2-NH2 ¦ OH with a compound having the formula Y-X, wherein X has the above defined meaning and Y is selected from halogen, -OH, -OK or -ONa; (B) reacting a compound of the formula -O-CH2-Z with a compound of the formula H2N-X, wherein X has the above-defined meaning and Z is selected from -CH-CH2 ANGLE O and -CH2-CH2-halogen; ¦ OH (C) reacting a phenol -OH with Z-CH2-NH-X, wherein X and Z have the meaning defined above.