| 摘要 |
<p>The present invention provides a novel process for the manufacture of 17- and 17a-carboxylic acids of the androstane and D-hemo-androstane series respectively,of the following partial formula of the ring D (I) wherein R represents a hydrogen atom or an unsubstituted or substituted hydrocarbon radical or a free or functionally ??dified hydroxyl group, and wherein the carboxyl group can be in the .alpha.- or .beta.-position, and of the salts and functional acid derivatives thereof, in particular their esters. The new process consists in the oxidative degradation of the side chain of corresponding 20, 21-ketoaldehydes of the pregnane or D-homopregnane series or of the 17.alpha.-pregnane or 17.alpha.a-D-homopregnane series with an organic peracid in an incrt solvent, preferably at temperatures betheen -20 and +30.degree.C.</p> |
