| 摘要 |
Drug delivery system comprises a number of particles of an active drug, each particle coated with a material (I) to form a composite particle which prevents the take up of the composite particle by the liver. - Pref. (I) provides the particles with both a hydrophilic coat that will minimise the uptake of blood components and a steric barrier to particle-cell interaction. Suitable (I) are the block copolymer Tetronic (RTM) 908, a Poloxamer (mixt. of polyoxythylene and polyoxypropylene domains) polymaleic acid or a polymer that is esterified to produce suitable hydrophilic and hydrophobic domains, polysaccharides, hyaluronic acid or xanthan gum.
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