| 摘要 |
The invention features methods of producing a preparation of very long lived epithelial cells, e.g., keratinocytes. The method includes providing a human epithelial tissue, e.g., epidermis; isolating at least one keratinocyte clone from the tissue; and determining if the clone is capable of at least 100, 150, 200, 250, 300, 350 or 400 population doublings after isolation from human tissue. Preparations of very long lived keratinocytes and methods of using the keratinocytes are also provided.
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