FOERFARANDE OCH MELLANPRODUKT FOER FRAMSTAELLNING AV SUBSTITUERADE PIPERIDINYLKINAZOLINER

摘要

2-(4-(1-hydroxy-1-substitutedmethyl)piperidino)-4-amino-6,7-dimethoxyq uinazolines with the formula in which R is a cycloalkyl containing 3 to 7 carbon atoms, an alkenyl containing 2 to 6 carbon atoms, or a benzyl group. The compounds are prepared e.g. by reacting methyl N-(2-cyano-4,5-dimethoxyphenyl)(4-(1-hydroxy-1-substitutedmethyl)piper idino)thioformamidate with ammonium chloride in formamide at about 120C. The compounds lower the blood pressure.