| 摘要 |
PROBLEM TO BE SOLVED: To provide processes for synthesizing bicyclic nucleoside antiviral compounds and synthesis of intermediates used in the process.SOLUTION: The invention provides the polymorphic form (II) of (S)-((2R,3S,5R)-(3-hydroxy-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidine-3(2H)-yl)-tetrahydrofuran-2-yl)methyl2-amino-3-methylbutanoate hydrochloride, characterized by a powder X-ray diffraction pattern including characteristic peaks at about 3.4, 6.9, 0.6, 12.1, 13.6, 14.4, 16.9, 17.6, 18.9, 20.1, 21.3 and 23.1 degrees 2θ.SELECTED DRAWING: None |
