| 发明名称 | Method for enhancing therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases | ||
| 摘要 | A method for enhancing the therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises pre-treating the stem cells with ligustilide to increase the expression of differentiation-promoting genes in the stem cells, increase the expression of homing-promoting genes in the stem cells, and/or decrease the expression of inflammatory genes in the stem cells, wherein the treatment is conducted in a culture medium of the stem cell. | ||
| 申请公布号 | US9518251(B2) | 申请公布日期 | 2016.12.13 |
| 申请号 | US201615074490 | 申请日期 | 2016.03.18 |
| 申请人 | GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD. | 发明人 | Lin Shinn-Zong;Harn Horng-Jyh;Fu Ru-Huei;Liu Shih-Ping;Lin Po-Cheng;Chuang Ming-Hsi |
| 分类号 | C12N5/00;C12N5/02;C12N5/0775;A61K35/545;A61K35/28 | 主分类号 | C12N5/00 |
| 代理机构 | Andrews Kurth LLP | 代理人 | Wang Ping;Andrews Kurth LLP |
| 主权项 | 1. A method for enhancing the therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases, comprising: a) pre-treating the stem cells by culturing the stem cells in a culture medium comprising 0.1 μg/ml to 20 μg/ml of ligustilide to increase the expression of differentiation-promoting genes in the stem cells, increase the expression of homing-promoting genes in the stem cells, and/or decrease the expression of inflammatory genes in the stem cells, wherein the culture medium does not comprise insulin; and b) administering an effective amount of stem cells pre-treated in step a) to a subject suffering from autoimmune diseases, cardiovascular diseases and/or hematological diseases. | ||
| 地址 | Zhubei, Hsinchu County TW | ||