发明名称 |
Chimeric antibody for detection and therapy of infectious and inflammatory lesions |
摘要 |
A chimeric antibody-agent conjugate for targeting foci of leukocyte accretion comprises a recombinant chimera having an antigen-binding hypervariable region which binds specifically to granulocytes, and a constant region of a human immunoglobulin having an Fc portion with high affinity for receptors on human mononuclear lymphoid cells, said chimera being conjugated to at least one diagnostic agent or therapeutic agent. A method for targeting an imaging or therapy agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above chimeric anti-leukocyte conjugate.
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申请公布号 |
US5637288(A) |
申请公布日期 |
1997.06.10 |
申请号 |
US19950457134 |
申请日期 |
1995.06.01 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
GOLDENBERG, DAVID M.;HANSEN, HANS J. |
分类号 |
A61K39/395;A61K45/00;A61K47/48;A61K49/00;A61K49/16;A61K51/00;A61K51/10;A61P29/00;A61P31/04;(IPC1-7):A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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