| 摘要 |
New cyanomethylthioacetylcephalosporins of the following general formula, and their salts WHEREIN R is hydrogen, lower alkyl, aralkyl, tri(lower alkyl)silyl, a salt forming ion or the group ; R1 and R2 each is hydrogen, lower alkyl, lower alkenyl, aryl or aralkyl, each of which may be substituted, or R1 and R2 may together complete a carbocyclic ring; R3 is hydrogen, lower alkyl, lower alkenyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, aryl, aralkyl or a heterocyclic group; R4 is lower alkyl, aryl or aralkyl and X is hydrogen, hydroxy, lower alkanoyloxy, lower alkoxy, lower alkylthio, aroyloxy, aralkanoyloxy, the radical of a nitrogen base, a quaternary ammonium radical or together X and R represent a bond linking carbon and oxygen in a lactone ring; are useful as antibacterial agents. |
