| 主权项 |
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: L1 is (C(R)2)n— and wherein n is 2 to 5; R1 is phenyl, wherein R1 is optionally substituted with p occurrences of Ra, wherein p is 0 to 2, inclusive; each Ra is independently selected from the group consisting of —R, —OR, —CN, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, and —N(R)2, or wherein Ra is an optionally substituted 5-6 membered monocyclic saturated, partially saturated, or aromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered saturated, partially saturated, or aromatic bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R is independently hydrogen, halogen, optionally substituted C1-6 aliphatic, optionally substituted phenyl, optionally substituted benzyl, or two R on the same nitrogen are taken together to form a 5-6 membered saturated, partially saturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
except for L1 and L2, where each R is independently hydrogen, halogen, optionally substituted phenyl, optionally substituted benzyl, or two R on the same nitrogen are taken together to form a 5-6 membered saturated, partially saturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and except for Rd where Rc is phenyl and each R is independently hydrogen, optionally substituted phenyl, optionally substituted benzyl, or two R on the same nitrogen are taken together to form a 5-6 membered saturated, partially saturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur L2 is —(C(R)2)m— and wherein m is 2 to 5; R2 is phenyl wherein R2 is optionally substituted with q occurrences of Rb, wherein q is 0 to 2; each Rb is independently selected from the group consisting of —R, —OR, —CN, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, and —N(R)2, or wherein Rb is an optionally substituted 5-6 membered monocyclic saturated, partially saturated, or aromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered saturated, partially saturated, or aromatic bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R3 and R3′ are independently hydrogen or halogen, or R3 and R3′ are taken together to form a C1 alkenylene optionally substituted with one or two Rc groups; each Rc is independently —R, —OR, —CN, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, or —NRSO2R, or wherein Rc is phenyl, a 5-6 membered monocyclic saturated, partially saturated, or aromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered saturated, partially saturated, or aromatic bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein Rc is optionally substituted with t occurrences of Rd, wherein t is 0 to 5, inclusive; and each Rd is independently —R, —OR, —CN, —C(R)3, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2; providing said compound is not |
