METHOD OF THE PRODUCTION OF VACCINE FOR PREVENTING INFECTION OF B-TYPE LIVER VIRUS

摘要

Hepatitis-infection preventing vaccine having HBsAg granules as chief ingredient was purified by intorducing the process of polyethylene glycol graduation to eliminate the B-type hepatitis-infectious ingredients. The HBsAg granules with particle size 22 nm and sp. gr. 1.19-1.21 g/cm3 were recovered by gel filtration and ultracentrifugal separation.