| 摘要 |
Novel fluorinated 1-( alpha -phenylalkyl)-1H-1,2,3-triazole compounds of the formula: <IMAGE> in which Ph denotes a phenyl radical which is substituted in the o-position by fluorine and optionally additionally by at least one further halogen atom, alk represents lower alkylidene, R1 denotes hydrogen, lower alkyl or an unsubstituted or lower alkanoyl- or lower alkyl-substituted carbamyl group and R2 represents an unsubstituted or lower alkanoyl or lower alkyl-substituted carbamyl group, have anticonvulsive properties and are utilisable as medicaments. They are prepared by reacting a compound of the formula <IMAGE> in which Y4 denotes esterified carboxyl and Y5 represents hydrogen, lower alkyl or, alternatively, esterified carboxyl, with an excess of ammonia or a di(lower alkylamine), and if desired lower-alkanoylating R2 and optionally R1 in a compound obtainable according to the process in which R2 and optionally R1 denote unsubstituted carbamyl. |
