7-substituted-delta?4Õ-6-azasteroid derivatives as 5alpha-reductase inhibitors

摘要

Compounds of the formula I I wherein R1 hydrogen or methyl; R2 is methyl; R3 hydrogen, Alk-R4, X-Alk, C1-6-X-Alk, XCO-Alk, CN, CO-Alk, CO-Ar, CO-O-Alk, CO-NH-Alk, CO-NH-Ar, CO-NH-Het and CO-N(Alk)2; Alk is C1-12 straight or branched alkyl; Ar is phenyl, Het is piperidinyl, piperizinyl, pyrrolidinyl, pyrrolyl, furanyl or thienyl and X is O, N or S. Such compounds are useful in the treatment of pathologic conditions that benefit from blockade of isozymes of 5 alpha -reductase.