发明名称 |
Methods for targeting the vasculature of solid tumors |
摘要 |
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
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申请公布号 |
US5776427(A) |
申请公布日期 |
1998.07.07 |
申请号 |
US19950456495 |
申请日期 |
1995.06.01 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
THORPE, PHILIP E.;BURROWS, FRANCIS J. |
分类号 |
A61K38/00;A61K47/48;A61K49/08;A61K51/10;A61P35/00;C07K16/22;C07K16/28;C07K16/30;C12P21/08;(IPC1-7):A61K51/10;A61K39/395;C07K16/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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