发明名称 |
Methods for identifying the toxic/pathologic effect of environmental stimuli on gene transcription |
摘要 |
Methods are disclosed for assessing the toxic or pathologic effects of a selected environmental stimulus or reagent on a mammalian cell by determining on a DNA grid a "fingerprint" hybridization pattern. The fingerprint pattern is characteristic of chemically or structurally diverse stimuli or reagents, which having a common adverse effect on gene transcription. A test compound is screened for a similar toxic effect by comparing its hybridization pattern on a similar grid to the fingerprint.
|
申请公布号 |
US2003224407(A1) |
申请公布日期 |
2003.12.04 |
申请号 |
US20030383212 |
申请日期 |
2003.03.06 |
申请人 |
BERTRAM TIMOTHY;BROWNE MICHAEL J.;BUGELSKI PETER;ENGLAND PAUL;MITCHELL IAN;MORGAN DAVID GWYN;RUT ANDREW |
发明人 |
BERTRAM TIMOTHY;BROWNE MICHAEL J.;BUGELSKI PETER;ENGLAND PAUL;MITCHELL IAN;MORGAN DAVID GWYN;RUT ANDREW |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68;G06F19/00;G01N33/48;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|