Substituted pyrido[1′,2′:4,5]pyrazino[1,2-a]azepines for treating viral infections

摘要

Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):;
including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

主权项

1. A compound having the following Formula (I): or a stereoisomer or pharmaceutically acceptable salt thereof, wherein:
Y1 and Y2 are each, independently, hydrogen, C1-3alkyl or C1-3haloalkyl;R1 is phenyl substituted with one to three halogens;X is —CHR2—;W is a bond;Z is —CHR4—;R2 and R4 are each, independently, hydrogen or C1-3alkyl;R5 is hydrogen, C1-3alkyl or C1-3haloalkyl;L is —C(Ra)2C(Ra)2C(Ra)2—; andeach Ra is, independently, hydrogen, halo, hydroxy or C1-4alkyl.