Substituted N-aryl pyridinones

摘要

Disclosed herein are substituted N-Aryl pyridinone fibrotic inhibitors and/or collagen infiltration modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.;

主权项

1. A method of treating or ameliorating one or more symptoms of a fibrotic-meditated disorder, a collagen-mediated disorder, or a fibrotic-mediated and collagen-mediated disorder in a patient in need of treatment, said method comprising administering to the patient a compound having the structure of Formula I: or a pharmaceutically acceptable salt, solvate, or prodrug thereof; wherein: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are independently selected from the group consisting of hydrogen and deuterium; at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 is deuterium; and at least one deuterium has a deuterium enrichment of no less than about 10%.