发明名称 |
Combination therapy with cryosurgery and low dosage strength imiquimod to treat actinic keratosis |
摘要 |
The present invention is directed to the use of complementary or combination lesion-directed therapy, such as cryosurgery, and field-directed therapy, such as low dose imiquimod topical therapy with short durations, in combination to treat actinic keratosis ("AK"). In carrying out the present invention, the lesion-directed and field-directed therapies may be applied sequentially or concomitantly, in accordance with the present invention. The novel complementary or combination AK therapy contemplated by the present invention: (1) significantly improves clearance of cryosurgery-treated Aks; (2) treats subclinical AK lesions; (3) treats those visible AK lesions in excess of that cryosurgery can actually treat in a single treatment due to, e.g., patient tolerance, provider treatment limits and/or cryosurgery cost to the patient; and (4) enhances sustained clearance overall, as compared to mono AK lesion- directed therapy. |
申请公布号 |
AU2011270724(B2) |
申请公布日期 |
2016.10.06 |
申请号 |
AU20110270724 |
申请日期 |
2011.06.24 |
申请人 |
Medicis Pharmaceutical Corporation |
发明人 |
Nordsiek, Michael T.;Levy, Sharon F.;Lee, James Hurn-joung;Kulp, James H.;Meng, Tze-chiang;Wu, Jason J.;Babilon, Robert;Balaji, Kodumudi S.;Bahm, Valyn S. |
分类号 |
A01N43/42;A61K31/44 |
主分类号 |
A01N43/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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