| 发明名称 |
POLYPEPTIDE CONSTRUCTS AND USES THEREOF |
| 摘要 |
The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen. |
| 申请公布号 |
US2016367695(A1) |
申请公布日期 |
2016.12.22 |
| 申请号 |
US201615194926 |
申请日期 |
2016.06.28 |
| 申请人 |
Teva Pharmaceuticals Australia Pty Ltd |
发明人 |
Wilson David S.;Pogue Sarah L.;Mikesell Glen E.;Taura Tetsuya;Korver Wouter;Doyle Anthony G.;Clarke Adam;Pollard Matthew;Tran Stephen;Lin Jack Tzu Chiao |
| 分类号 |
A61K47/48;C07K16/28 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide construct, comprising an antibody that specifically binds to CD38, or antigen binding portion thereof, linked to an attenuated interferon α2b (IFN α2b) comprising at least one attenuating amino acid substitution. |
| 地址 |
Macquarie Park AU |
