| 摘要 |
The present invention addresses the problem of providing an artificial promoter which exhibits nerve activity-dependent activity and high sensitivity and has a great dynamic range, and of providing a method for identifying a nerve activity site by using said promoter. The present invention provides a DNA exhibiting nerve activity-dependent promoter activity, wherein a fragment containing the CREB binding site, the MEF2 binding site and the SRF binding site from among the synaptic activity-responsive elements (SAREs) on the promoter of an Arc/Arg3.1 gene contains a construct that is connected in tandem at least twice. |
