发明名称 |
A METHOD FOR DETERMINING METASTATIC BREAST CANCER, MONITORING RESPONSE TO THERAPY AND RECURRENCE OF BREAST CANCER |
摘要 |
A method of monitoring a breast cancer patient's response to treatment, or of detecting recurrence of breast cancer, the method comprising a step of assaying a plurality of samples obtained from the patient over a period of time for expression levels of a plurality of biomarkers including Cancer Antigen 15-3 (CA 15-3) and one of either Glutamate or 12-Hydroxyeicosatetraenoic acid (12-HETE), and detecting a change in expression levels of CA 15-3 and one (or both) of either Glutamate or 12-HETE over the time period, wherein detection of a decreased expression levels of CA 15-3 and one of either Glutamate or 12-HETE over the time period is indicative of a response to therapy and wherein detection of increased or stable expression levels of CA 15-3 and one of either Glutamate or 12-HETE over the time period is indicative of a non-response to breast cancer therapy. |
申请公布号 |
EP3102948(A1) |
申请公布日期 |
2016.12.14 |
申请号 |
EP20150707558 |
申请日期 |
2015.02.05 |
申请人 |
Dublin City University |
发明人 |
CLYNES, Martin;DOWLING, Paul;CLARKE, Colin |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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