URODELE EXOSOMES AS THERAPEUTIC AGENTS

摘要

Described herein are compositions and techniques related to generation and therapeutic application of urodele cell derived exosomes. Urodeles such as newts and salamanders, are highly regenerative animals. There is increasing evidence that exosomes are vital actors potentiating repair and regenerative activity. Here, it is described that urodele derived cellular exosomes are bioactive in mammals, and promote rat cardiomyocyte proliferation, increase SDF-1 secretion by human dermal fibroblasts, and improve functional recovery after myocardial infarct in rats. Described herein are compositions and techniques allowing for protection against and/or reversal of disease pathology in heart and vascular disease.