Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof

摘要

A method for treating and/or diagnosing pain and the source or type of pain, shock, and/or inflammatory conditions in a subject. A method of using a therapeutically effective amount of a DNA or RNA aptamer that shows high affinity for OLAMs to at least partially treat pain, shock, and/or inflammatory conditions in a subject. The DNA or RNA aptamer that shows high affinity for OLAMs may be coupled to a plasma protein binding compound or a pharmacologically active agent. A method of treating and or diagnosing pain, shock, and/or inflammatory conditions in a subject may include inactivating or preventing at least one linoleic acid metabolite to treat certain conditions (e.g., pain, shock, and/or inflammation) using a DNA or RNA aptamer that shows high affinity for OLAMs.

主权项

1. A compound comprising an aptamer having the structure 5′- ATC CGT CAC ACC TGC TCT GCA TGG CCA TCC AGA TTA GTC CTG CAG CAC ATT CGG TGG TGT TGG CTC CCG TAT -3′ (SEQ ID NO: 85).