Ventricular pacing to augment atrial natriuretic hormone production

摘要

Intermittent delivery of ventricular pacing pulses synchronized to occur during an atrial diastole time period can be used to provide atrial stretch therapy and augment the production and release of atrial natriuretic hormone.

主权项

1. A method, comprising:
monitoring a first physiological parameter of a subject; detecting whether the first physiological parameter meets a first criteria for triggering use of an atrial stretch therapy mode by a cardiac rhythm management device; and responding to detecting that the first physiological parameter meets the first criteria by switching the cardiac rhythm management device from a first operating mode to the atrial stretch therapy mode, the atrial stretch therapy mode configured to time delivery of a pace so that: (1) delivery of the pace results in a substantial overlap of ventricular systole and atrial systole, and (2) a ventricular contraction occurs before or substantially concurrent with an atrial contraction during the same cardiac cycle.