DOSE SELECTION OF ADJUVANTED SYNTHETIC NANOCARRIERS

摘要

Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods. WO 2011/150258 PCT/US2011/038210 SYSTEMIC TNF-a PRODUCTION UPON NC INOCULATION (3 MICE/GROUP) ----- NC-R848-1 --- v--- NC-R848-2 2000- ----- NC ONLY E -- NC ONLY+ R848 0 1 2 3 4 5 6 TIME AFTER INJECTION (HOURS) Fig. 1 A SYSTEMIC IL-6 PRODUCTION UPON NC INOCULATION (3 MICE/GROUP) --- A-- NC-R848-1 --- v--- NC-R848-2 4000- ----- NC ONLY -n-NC ONLY+ R848 i 2000 0 1 2 3 4 5 6 7 TIME AFTER INOCULATION (HRS) Fig. 1B