Compositions comprising <i>Neisseria meningitidis </i>antigens from serogroups B and C

摘要

International patent application WO99/61053 discloses immunogenic compositions that comprise N. meningitidis serogroup C oligosaccharide conjugated to a carrier, in combination with N. meningitidis serogroup B outer membrane protein. These are disclosed in the present application in combination with further Neisserial proteins and/or protective antigens against other pathogenic organisms (e.g. Haemophilus influenzae, DTP, HBV, etc.).

主权项

1. A composition comprising (a) Neisseria meningitidis C (NmC) oligosaccharide conjugated to a carrier protein, (b) Neisseria meningitidis B (NmB) outer membrane protein, and (c) an isolated polypeptide comprising an amino acid sequence having 80% or greater sequence identity to SEQ ID NO: 601, wherein the components (a), (b) and (c) were mixed together and wherein the composition comprises a carrier-adjuvant selected from aluminum hydroxide, aluminum phosphate, and an oil-in-water emulsion.