LIQUID PHARMACEUTICAL COMPOSITION OF CONJUGATED ERYTHROPOIETIN

摘要

A liquid pharmaceutical composition having a conjugated erythropoietin, buffer, sugar, tonicity modifier and amino acid as an aggregation inhibitor. The liquid pharmaceutical composition provides a stable pharmaceutical composition which encompasses conjugated erythropoietin, acetate buffer, sucrose, arginine and sodium chloride which is maintained at a pH of about 4.9 to 5.3.

主权项

1. A liquid pharmaceutical formulation comprising: a conjugated EPO, and a buffer which is selected from the group consisiting of acetate, arginine, histidine, succinate or a combination thereof, an aggregation inhibitor, sodium chloride as tonicity modifier and sucrose as stabilizer wherein the pH of the formulation is between 4.9 to 5.3.