| 发明名称 |
USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXMIN |
| 摘要 |
Polyols stabilize polymorphous form of rifaximin, in particular the β form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph β is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described. |
| 申请公布号 |
US2017101417(A1) |
申请公布日期 |
2017.04.13 |
| 申请号 |
US201615153636 |
申请日期 |
2016.05.12 |
| 申请人 |
ALFA WASSERMANN S.P.A. |
发明人 |
MAFFEI Paola;BACHETTI Milena;BOTTONI Giuseppe;VISCOMI Giuseppe Claudio |
| 分类号 |
C07D491/22 |
主分类号 |
C07D491/22 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. Use of one or more compounds (herein defined as “polyols”) bearing at least two hydroxy groups to stabilize polymorphous forms of rifaximin. |
| 地址 |
Alanno IT |
